As a classical trained percussionist, Lê Quan Ninh worked with contemporary music ensembles and was a founder member of Quatuor Hêlios (1986-2012), a percussion quartet that performed and recorded, among others, John Cage's percussion works. Their last creation was Seul à Seuls by Georges Aperghis premiered in late 2006 at the Musica Festival in Strasbourg (France).

As an improvisor, he participates at numerous meetings in Europe and in North America and plays regularly in ensembles in forms that mix improvised acoustic & electroacoustic music, 'performance art', dance, poetry, experimental cinema, photography and video.

With the cellist Martine Altenburger, he founded in 2006 the ensemble]h[iatus, a contemporary music ensemble whose its members are at the same time interpreters and improvisers. They commissioned pieces to the composers Vinko Globokar, Peter Jakober, Steffen Krebber, Jennifer Walshe and Anthony Pateras

His discography counts about 40 CD on european and north american labels. The last release (Aplomb, 2015) is a duet with his long term colleague Michel Doneda.

In 2014, he publishes the translation of his book Improvising Freely. The ABCs of an Experience (previously published in french). The book is available here